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Importantly, serum B12 levels can be misleadingly normal or even elevated in chronic liver disease due to increased levels of binding proteins (such as haptocorrin) and reduced clearance, meaning that total B12 measurements may not accurately reflect tissue B12 status or functional deficiency

Allergies and medical conditions Those with allergies or medical conditions should always inform a doctor before receiving a vitamin B12 shot

Journal of Physiology-Paris , 87(5), 313327

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Clinical Update 1/27/2026 High-Dose B-12 for Nerve Pain

TO INJECT INTRAMUSCULARLY Flick the ampoule to get all the B12 into the bottom .Open it by either wrapping a swab around it to avoid cutting yourself , or use an ampoule opener